Advanced glycation end products (AGE) and receptor for AGE (RAGE) in patients with active tuberculosis, and their relationship between food intake and nutritional status.,PLOS ONE

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Advanced glycation end products (AGE) and receptor for AGE (RAGE) in patients with active tuberculosis, and their relationship between food intake and nutritional status.
PLOS ONE ( IF 2.9 ) Pub Date : 2019-03-14 , DOI: 10.1371/journal.pone.0213991
Lívia Fontes da Silva ₁ , Erika Cavalheiro Skupien ₁ , Tássia Kirchmann Lazzari ₁ , Sizuane Rieger Holler ₂ , Ellis Gabriela Correa de Almeida ₂ , Luísa Rebechi Zampieri ₃ , Sandra Eugênia Coutinho ₁ , Michael Andrades ₄ , Denise Rossato Silva _{1,

2}

Affiliation

INTRODUCTION The receptor for advanced glycation end products (RAGE) is expressed in normal lungs and is upregulated during infection. AGEs and RAGE cause oxidative stress and apoptosis in lung cells. The objective of this study is to evaluate levels of AGEs and its soluble receptor (sRAGE), and to investigate their relationship with food intake and nutritional status, in a university-affiliated hospital in Brazil. METHODS Case-control study, from June 2017 to June 2018. AGE (carboxymethyl lysine, CML) and sRAGE were measured from blood samples by Elisa. Nutritional assessment was performed by body mass index, triceps skin-fold thickness, mid-arm circumference, mid-arm muscle circumference, bioelectrical impedance analysis, and food frequency questionnaire. RESULTS We included in the study 35 tuberculosis (TB) patients and 35 controls. The mean sRAGE levels were higher in TB patients than in controls (68.5 ± 28.1 vs 57.5 ± 24.0 pg/mL; p = 0.046). Among cases that were current smokers, lower sRAGE levels were associated with mortality, evaluated at the end of hospitalization (p = 0.006), and with weight loss (p = 0.034). There was no statistically significant difference in CML levels and diet CML content between cases and controls. Malnutrition was more frequent in cases, but there was no correlation between nutritional parameters and CML or sRAGE levels. CONCLUSIONS TB patients had higher sRAGE levels than controls, although it is not clear that this difference is clinically relevant. Also, sRAGE was associated with weight loss and mortality.

中文翻译：

活动性结核病患者的晚期糖基化终末产物（AGE）和AGE受体（RAGE）及其与食物摄入和营养状况之间的关系。

引言晚期糖基化终产物的受体（RAGE）在正常肺中表达，在感染过程中被上调。AGEs和RAGE会引起肺细胞氧化应激和细胞凋亡。这项研究的目的是评估巴西一家大学附属医院中AGEs及其可溶性受体（sRAGE）的水平，并研究其与食物摄入和营养状况之间的关系。方法病例对照研究，2017年6月至2018年6月。Elisa从血液样本中测量AGE（羧甲基赖氨酸，CML）和sRAGE。通过体重指数，肱三头肌皮肤折叠厚度，手臂中部圆周，手臂中部肌肉圆周，生物电阻抗分析和食物频率调查表进行营养评估。结果我们在研究中纳入了35名结核病患者和35名对照。结核病患者的平均sRAGE水平高于对照组（68.5±28.1 vs 57.5±24.0 pg / mL； p = 0.046）。在目前吸烟的患者中，较低的sRAGE水平与死亡率相关，在住院结束时进行评估（p = 0.006）和体重减轻（p = 0.034）。病例和对照之间的CML水平和饮食中CML含量没有统计学上的显着差异。营养不良的情况更为常见，但营养参数与CML或sRAGE水平之间没有相关性。结论结核病患者的sRAGE水平高于对照组，尽管尚不清楚这种差异是否与临床相关。同样，sRAGE与体重减轻和死亡率有关。在目前吸烟的患者中，较低的sRAGE水平与死亡率，住院结束时的评估有关（p = 0.006）和体重减轻（p = 0.034）。病例和对照之间的CML水平和饮食中CML含量没有统计学上的显着差异。营养不良的情况更为常见，但营养参数与CML或sRAGE水平之间没有相关性。结论结核病患者的sRAGE水平高于对照组，尽管尚不清楚这种差异是否与临床相关。同样，sRAGE与体重减轻和死亡率有关。在目前吸烟的患者中，较低的sRAGE水平与死亡率，住院结束时的评估有关（p = 0.006）和体重减轻（p = 0.034）。病例和对照之间的CML水平和饮食中CML含量没有统计学上的显着差异。营养不良的情况更为常见，但营养参数与CML或sRAGE水平之间没有相关性。结论结核病患者的sRAGE水平高于对照组，尽管尚不清楚这种差异是否与临床相关。同样，sRAGE与体重减轻和死亡率有关。病例和对照之间的CML水平和饮食中CML含量没有统计学上的显着差异。营养不良的情况更为常见，但营养参数与CML或sRAGE水平之间没有相关性。结论结核病患者的sRAGE水平高于对照组，尽管尚不清楚这种差异是否与临床相关。同样，sRAGE与体重减轻和死亡率有关。病例和对照之间的CML水平和饮食中CML含量没有统计学上的显着差异。营养不良的情况更为常见，但营养参数与CML或sRAGE水平之间没有相关性。结论结核病患者的sRAGE水平高于对照组，尽管尚不清楚这种差异是否与临床相关。同样，sRAGE与体重减轻和死亡率有关。

更新日期：2019-03-15

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