Patients with Alzheimer's disease (AD) often exhibit motion processing deficits. It is unclear whether the localization of moving objects – a perceptual process tightly linked to motion – is impaired or intact in AD. In this study, we used the phenomenon of illusory shift of position induced by motion as a behavioural paradigm to probe how the spatial representation differs between AD patients and healthy elderly controls. We measured the magnitudes of motion‐induced position shift in a group of AD participants (N = 24) and age‐matched elderly observers (N = 24). We found that AD patients showed weakened position mis‐localization, but only for motion stimuli of slow speeds. For fast motion, the position mis‐localization did not differ significantly between groups. Furthermore, we showed that the magnitudes of position mis‐localization can predict the severity of AD; that is, patients with more severe symptoms had less preserved position mis‐localization. Our results suggest that AD pathology impacts not only motion processing per se, but also the perceptual process related to motion such as the localization of moving objects.

中文翻译：

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运动引起的位置错误定位预测了阿尔茨海默氏病的严重程度。

患有阿尔茨海默氏病（AD）的患者通常表现出运动过程缺陷。目前尚不清楚运动对象的定位（与运动紧密相关的感知过程）是否在AD中受损或完好无损。在这项研究中，我们将运动引起的错觉位置错位现象作为一种行为范式，以探讨AD患者与健康的老年人对照之间的空间表现形式如何不同。我们测量了一组AD参与者（N  = 24）和年龄匹配的老年观察者（N = 24）。我们发现，AD患者显示出弱的位置错误定位，但仅适用于慢速运动刺激。对于快动作，两组之间的位置错误定位没有显着差异。此外，我们证明了位置错误定位的幅度可以预测AD的严重程度。也就是说，症状较严重的患者保留的位置错误定位较少。我们的结果表明，AD病理不仅影响运动处理本身，而且影响与运动有关的感知过程，例如运动对象的定位。