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Vitamin D and diabetic foot ulcer: a systematic review and meta-analysis.
Nutrition & Diabetes ( IF 4.6 ) Pub Date : 2019-03-11 , DOI: 10.1038/s41387-019-0078-9 Jiezhi Dai 1 , Chaoyin Jiang 1 , Hua Chen 1 , Yimin Chai 1
Nutrition & Diabetes ( IF 4.6 ) Pub Date : 2019-03-11 , DOI: 10.1038/s41387-019-0078-9 Jiezhi Dai 1 , Chaoyin Jiang 1 , Hua Chen 1 , Yimin Chai 1
Affiliation
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We aimed to evaluate the association between vitamin D deficiency and diabetic foot ulcer (DFU) in patients with diabetes. Pubmed, EMBASE, BIOSIS, the Cochrane Library, and Web of Knowledge, last updated in July 2018, were searched. We assessed eligible studies for the association between vitamin D deficiency and DFU in diabetic patients. The mean difference (MD) or the odds ratio (OR) was calculated for continuous or dichotomous data respectively. Data were analyzed by using the Cochrane Collaboration's RevMan 5.0 software. Seven studies that involved 1115 patients were included in this study. There were significantly reduced vitamin D levels in DFU (MD -13.47 nmol/L, 95%CI -16.84 to -10.10; P = 0.34, I2 = 12%). Severe vitamin D deficiency was significantly associated with an increased risk of DFU (OR 3.22, 95%CI 2.42-4.28; P = 0.64, I2 = 0%). This is the first meta-analysis demonstrating the association between serum vitamin D levels and DFU. Severe vitamin D deficiency is significantly associated with an increased risk of DFU.
中文翻译：
维生素D和糖尿病足溃疡：系统评价和荟萃分析。
我们旨在评估维生素D缺乏症与糖尿病患者糖尿病足溃疡（DFU）之间的关联。搜索了最近于2018年7月更新的Pubmed，EMBASE，BIOSIS，Cochrane库和Web of Knowledge。我们评估了糖尿病患者维生素D缺乏与DFU之间关联的合格研究。分别针对连续或二分数据计算平均差（MD）或优势比（OR）。使用Cochrane Collaboration的RevMan 5.0软件对数据进行了分析。这项研究包括7项研究，涉及1115名患者。DFU中的维生素D水平显着降低（MD -13.47 nmol / L，95％CI -16.84至-10.10; P = 0.34，I2 = 12％）。严重的维生素D缺乏症与DFU风险增加显着相关（OR 3.22，95％CI 2.42-4.28； P = 0.64，I2 = 0％）。这是首次证明血清维生素D水平与DFU之间存在关联的荟萃分析。严重的维生素D缺乏症与DFU风险增加显着相关。
更新日期：2019-03-11
中文翻译：
维生素D和糖尿病足溃疡：系统评价和荟萃分析。
我们旨在评估维生素D缺乏症与糖尿病患者糖尿病足溃疡（DFU）之间的关联。搜索了最近于2018年7月更新的Pubmed，EMBASE，BIOSIS，Cochrane库和Web of Knowledge。我们评估了糖尿病患者维生素D缺乏与DFU之间关联的合格研究。分别针对连续或二分数据计算平均差（MD）或优势比（OR）。使用Cochrane Collaboration的RevMan 5.0软件对数据进行了分析。这项研究包括7项研究，涉及1115名患者。DFU中的维生素D水平显着降低（MD -13.47 nmol / L，95％CI -16.84至-10.10; P = 0.34，I2 = 12％）。严重的维生素D缺乏症与DFU风险增加显着相关（OR 3.22，95％CI 2.42-4.28； P = 0.64，I2 = 0％）。这是首次证明血清维生素D水平与DFU之间存在关联的荟萃分析。严重的维生素D缺乏症与DFU风险增加显着相关。
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