The paralogous transcriptional co-activators CBP and p300 (aka KAT3A and KAT3B, respectively) contain a characteristic and promiscuous lysine acetyltransferase (KAT) domain and multiple independent protein-binding domains that enable them to interact with hundreds of proteins, possibly promoting the acetylation of thousands of target lysine residues. Both proteins play critical roles during the development of the nervous system and may also regulate stimuli-driven transcription and plasticity in postmitotic neurons. The multiplicity of functions, substrates, and molecular partners, together with the redundancy and singularity of the two KAT3 paralogs, define a complex cat's cradle of relationships. In this review, we discuss the role of the KAT3 proteins in neurons and integrate recent information regarding their function and mode of action.

中文翻译：

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在大脑发育和可塑性方面的CBP / p300：解开KAT的摇篮。

旁系转录共激活因子CBP和p300（分别为KAT3A和KAT3B）包含特征性和混杂的赖氨酸乙酰转移酶（KAT）结构域以及多个独立的蛋白结合结构域，这些结构域使它们能够与数百种蛋白相互作用，从而可能促进BNP的乙酰化数千个目标赖氨酸残基。两种蛋白质在神经系统发育过程中都起着至关重要的作用，并且还可能调节有丝分裂后神经元中刺激驱动的转录和可塑性。功能，底物和分子伴侣的多样性，以及两个KAT3旁系同源物的冗余和奇异，定义了复杂的关系摇篮。在这篇综述中，我们讨论了KAT3蛋白在神经元中的作用，并整合了有关其功能和作用方式的最新信息。