Calcium fluxes through the neuronal membrane are strictly limited in time due to biophysical properties of voltage-gated and ligand-activated ion channels and receptors. Being embedded into the crowded dynamic environment of biological membranes, Ca2+-permeable receptors and channels undergo perpetual spatial rearrangement, which enables their temporary association and formation of transient signalling complexes. Thus, efficient calcium-mediated signal transduction requires mechanisms to support very precise spatiotemporal alignment of the calcium source and Ca2+-binding lipids and proteins in a highly dynamic environment. The mobility of calcium channels and calcium-sensing proteins themselves can be considered as a physiologically meaningful variable that affects calcium-mediated signalling in neurons. In this review, we will focus on voltage-gated calcium channels (VGCCs) and activity-induced relocation of stromal interaction molecules (STIMs) in the endoplasmic reticulum (ER) to show that particularly in time ranges between milliseconds to minutes, dynamic rearrangement of calcium conducting channels and sensor molecules is of physiological relevance. This article is part of the special issue entitled 'Mobility and trafficking of neuronal membrane proteins'.

中文翻译：

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神经元中钙通道信号的动态区室化。

由于电压门控和配体激活的离子通道和受体的生物物理特性，严格限制了通过神经元膜的钙流量。嵌入到生物膜拥挤的动态环境中，可渗透Ca2 +的受体和通道会发生永久性的空间重排，从而使其能够临时缔合并形成瞬时信号复合物。因此，有效的钙介导的信号转导需要在高动态环境中支持钙源以及与Ca2 +结合的脂质和蛋白质非常精确的时空比对的机制。钙通道和钙敏感蛋白本身的移动性可以被认为是影响神经元中钙介导的信号传导的生理学有意义的变量。在这篇评论中，我们将重点研究电压门控钙通道（VGCC）和内质网（ER）中由活性引起的基质相互作用分子（STIM）的重新定位，以显示特别是在毫秒到分钟之间的时间范围内，钙传导通道的动态重排和传感器分子具有生理相关性。本文是题为“神经元膜蛋白的移动性和运输”的特刊的一部分。