The development of miniaturized and field portable mass spectrometers could not succeed without a simple, compact, and robust ionization source. Here we present a voltage‐free ionization method, Vibrating Sharp‐edge Spray Ionization (VSSI), which can generate a spray of liquid samples using only one standard microscope glass slide to which a piezoelectric transducer is attached. Compared with existing ambient ionization methods, VSSI eliminates the need for a high electric field (~5000 V·cm⁻¹) for spray generation, while sharing a similar level of simplicity and flexibility with the simplest direct ionization techniques currently available such as paper spray ionization (PSI) and other solid substrate‐based electrospray ionization methods.

中文翻译：

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使用质谱法对样品进行无电压直接分析的振动锐边喷雾电离 (VSSI)

如果没有简单、紧凑和坚固的电离源，小型化和现场便携式质谱仪的开发就不可能成功。在这里，我们提出了一种无电压电离方法，振动锐边喷雾电离 (VSSI)，它可以仅使用一个连接有压电换能器的标准显微镜载玻片来产生液体样品的喷雾。与现有的环境电离方法相比，VSSI 无需高电场 (~5000 V·cm ^-1 ) 来产生喷雾，同时与目前可用的最简单的直接电离技术（如纸喷雾）具有相似的简单性和灵活性电离 (PSI) 和其他基于固体基质的电喷雾电离方法。