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Carotid Intima-Media Thickness and Markers of Brain Health in a Biracial Middle-Aged Cohort: CARDIA Brain MRI Sub-study.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 4.3 ) Pub Date : 2020-01-20 , DOI: 10.1093/gerona/glz039
Pavla Cermakova 1, 2 , Jie Ding 3 , Osorio Meirelles 3 , Jared Reis 4 , Dorota Religa 5, 6 , Pamela J Schreiner 7 , David R Jacobs 7 , R Nick Bryan 8 , Lenore J Launer 3
Affiliation  

BACKGROUND We investigated whether carotid intima-media thickness is associated with measures of cerebral blood flow (CBF), white matter hyperintensities, and brain volume in a biracial cohort of middle-aged individuals. METHODS We performed a cross-sectional cohort study based on data from a multicenter, population-based study Coronary Artery Risk Development in Young Adults. Using linear and logistic regression, we estimated the association of the composite intima-media thickness measured in three segments of carotid arteries (common carotid artery, carotid artery bulb, and internal carotid artery) with volume (cm3) and CBF (mL/100 g/min) in the total brain and gray matter as well as volume of white matter hyperintensities (cm3). RESULTS In the analysis, 461 participants (54% women, 34% African Americans) were included. Greater intima-media thickness was associated with lower CBF in gray matter (β=-1.36; p = .04) and total brain (β=-1.26; p = .04), adjusting for age, sex, race, education, and total brain volume. The associations became statistically nonsignificant after further controlling for cardiovascular risk factors. Intima-media thickness was not associated with volumes of total brain, gray matter, and white matter hyperintensities. CONCLUSIONS This study suggests that lower CBF in middle age is associated with markers of atherosclerosis in the carotid arteries. This association may reflect early long-term exposure to traditional cardiovascular risk factors. Early intervention on atherosclerotic risk factors may modulate the trajectory of CBF as people age and develop brain pathology.

中文翻译:

混血儿中年人群的颈动脉内膜中层厚度和脑部健康状况的标记:CARDIA脑MRI子研究。

背景我们研究了中年人混血儿队列中颈动脉内膜中层厚度是否与脑血流量(CBF),白质高信号和脑容量的测量有关。方法我们基于一项基于多中心,以人群为基础的研究显示的年轻人冠状动脉风险发展的数据,进行了一项横断面队列研究。使用线性和逻辑回归,我们估计了在三段颈动脉(普通颈动脉,颈动脉球和颈内动脉)中测量的复合内膜中膜厚度与体积(cm3)和CBF(mL / 100 g)的相关性/ min),以及总的脑白质和灰质超量(cm3)。结果在分析中,包括461名参与者(女性为54%,非裔美国人为34%)。调整了年龄,性别,种族,文化程度和年龄后,灰质(β= -1.36; p = .04)和全脑(β= -1.26; p = .04)的CBF较低与内膜中层厚度增加相关。总脑容量。在进一步控制心血管危险因素后,该关联在统计学上不显着。内膜中层厚度与总脑容量,灰质和白质高信号强度无关。结论该研究表明中年CBF降低与颈动脉粥样硬化的标志物有关。这种关联可能反映出早期长期接触传统的心血管危险因素。随着人们年龄的增长和脑部病理的发展,对动脉粥样硬化危险因素的早期干预可能会调节CBF的轨迹。04)和总脑(β= -1.26; p = .04),并根据年龄,性别,种族,教育程度和总脑容量进行了调整。在进一步控制心血管危险因素后,该关联在统计学上不显着。内膜中层厚度与总脑容量,灰质和白质高信号强度无关。结论该研究表明中年CBF降低与颈动脉粥样硬化的标志物有关。这种关联可能反映出早期长期接触传统的心血管危险因素。早期干预动脉粥样硬化危险因素可能会随着人的年龄增长和脑部病理改变而调节CBF的轨迹。04)和总脑(β= -1.26; p = .04),并根据年龄,性别,种族,教育程度和总脑容量进行了调整。在进一步控制心血管危险因素后,该关联在统计学上不显着。内膜中层厚度与总脑容量,灰质和白质高信号强度无关。结论该研究表明中年CBF降低与颈动脉粥样硬化的标志物有关。这种关联可能反映出早期长期接触传统的心血管危险因素。早期干预动脉粥样硬化危险因素可能会随着人的年龄增长和脑部病理改变而调节CBF的轨迹。在进一步控制心血管危险因素后,该关联在统计学上不显着。内膜中层厚度与总脑容量,灰质和白质高信号强度无关。结论该研究表明中年CBF降低与颈动脉粥样硬化的标志物有关。这种关联可能反映出早期长期接触传统的心血管危险因素。早期干预动脉粥样硬化危险因素可能会随着人的年龄增长和脑部病理改变而调节CBF的轨迹。在进一步控制心血管危险因素后,该关联在统计学上不显着。内膜中层厚度与总脑容量,灰质和白质高信号强度无关。结论该研究表明中年CBF降低与颈动脉粥样硬化的标志物有关。这种关联可能反映出早期长期接触传统的心血管危险因素。早期干预动脉粥样硬化危险因素可能会随着人的年龄增长和脑部病理改变而调节CBF的轨迹。结论该研究表明中年CBF降低与颈动脉粥样硬化的标志物有关。这种关联可能反映出早期长期接触传统的心血管危险因素。早期干预动脉粥样硬化危险因素可能会随着人的年龄增长和脑部病理改变而调节CBF的轨迹。结论该研究表明中年CBF降低与颈动脉粥样硬化的标志物有关。这种关联可能反映出早期长期接触传统的心血管危险因素。早期干预动脉粥样硬化危险因素可能会随着人的年龄增长和脑部病理改变而调节CBF的轨迹。
更新日期:2020-01-21
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