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Epigenetic clock analysis of blood samples from Japanese schizophrenia patients.
npj Schizophrenia ( IF 5.7 ) Pub Date : 2019-02-27 , DOI: 10.1038/s41537-019-0072-1
Satoshi Okazaki 1 , Ikuo Otsuka 1 , Shusuke Numata 2 , Tadasu Horai 1 , Kentaro Mouri 3, 4 , Shuken Boku 1 , Tetsuro Ohmori 2 , Ichiro Sora 1 , Akitoyo Hishimoto 1
Affiliation  

The accelerated aging hypothesis of schizophrenia (SCZ) has been proposed. DNA methylation profiles were developed for determining "epigenetic age." Here, we assessed intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA, respectively) in SCZ. We examined two independent cohorts of Japanese ancestry. The first cohort consisted of 80 patients with SCZ under long-term or repeated hospitalization and 40 controls, with the economical DNA pooling technique. The second cohort consisted of 24 medication-free patients with SCZ and 23 controls. Blood of SCZ subjects exhibited decreased EEAA in the first cohort (p = 0.0162), but not in the second cohort. IEAA did not differ in either cohort. We performed replication analyses using publicly available datasets from European ancestry (three blood and one brain datasets). One blood dataset showed increased EEAA in SCZ (p = 0.0228). Overall, our results provide evidence for decreased EEAA in SCZ associated with hospitalization in the Japanese population.

中文翻译:

日本精神分裂症患者血液样本的表观遗传时钟分析。

精神分裂症(SCZ)的加速衰老假说已被提出。开发了DNA甲基化谱用于确定“表观遗传年龄”。在这里,我们评估了SCZ的内在和外在表观遗传年龄加速(分别为IEAA和EEAA)。我们研究了两个日本血统的独立队列。第一组包括80名长期或反复住院的SCZ患者和40名采用经济的DNA合并技术的对照组。第二个队列由24名SCZ的无药物治疗患者和23名对照组组成。SCZ受试者的血液在第一个队列中显示出降低的EEAA(p = 0.0162),而在第二个队列中则没有。IEAA在这两个队列中都没有差异。我们使用来自欧洲血统的公开可用数据集(三个血液和一个大脑数据集)进行了复制分析。一个血液数据集显示SCZ中的EEAA升高(p = 0.0228)。总体而言,我们的结果提供了与日本人群住院相关的SCZ EEAA降低的证据。
更新日期:2019-02-27
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