The reaction of N-unprotected methylesters of phenylglycine derivatives (1a–1f) with electron-rich internal alkynes (2a–2e), catalyzed by [Ru(cymene)Cl₂]₂ (10%), gives the corresponding 3,4-disubstituted isoquinoline-1-carboxylates 3 through CH/NH oxidative coupling. The CH bond activation step is assisted by carboxylates, and N-fluoro-2,4,6-trimethylpyridinium triflate works as the terminal oxidant. The process shows a remarkable tolerance to the presence of diverse electron-releasing and electron-attracting functional groups at the phenyl ring of the amino acid. In addition, the reaction of phenylglycine derivatives (1a–1f) with methyl acrylate (4a) catalyzed by [Ru(cymene)Cl₂]₂ (10%) under the same experimental conditions, gives the corresponding 3,N-disubstituted isoindoline-1-carboxylates 5 through CH/NH coupling. Isoindolines 5 are obtained as a mixture of diastereoisomers, with moderate to high values of diastereomeric excess (up to 80%).

在[Ru（cymene）Cl ₂ ] ₂（10％）的催化下，苯甘氨酸衍生物（1a-1f）的N-未保护的甲基酯与富含电子的内部炔烃（2a-2e）的反应，得到相应的3,4-双取代的异喹啉-1-羧酸酯3通过C H / N H氧化偶合。C H键活化步骤由羧酸盐协助，并且三氟甲磺酸N-氟-2,4,6-三甲基吡啶鎓用作末端氧化剂。该方法显示出对氨基酸的苯环上存在各种释放电子和吸引电子的官能团的显着耐受性。此外，苯甘氨酸衍生物（1a–1f的反应在相同的实验条件下，用[Ru（cymene）Cl ₂ ] ₂（10％）催化的丙烯酸甲酯（4a），通过C H / N H偶合得到相应的3，N-二取代的异吲哚啉-1-羧酸酯5。以非对映异构体的混合物形式获得异二氢吲哚5，具有中等至高的非对映异构体过量值（最高80％）。