Acceleration of palladium catalyzed CH activation by various Lewis Acids was demonstrated on the directed ortho-alkenylation and acylation of acetanilide and urea derivatives. The universality of this effect was investigated by the study of different palladium catalysts, directing groups in the aromatic substrates and versatile Lewis acids. Experiments were carried out to monitor the reactions and to compare the behavior and activity of different types of Lewis acids. Kinetic investigation revealed a rate determining CH activation step, and DFT studies were performed for the explanation of Lewis acid effect on CH activation.

中文翻译：

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路易斯酸加速钯催化C H活化的研究

在乙酰苯胺和脲衍生物的直接邻链烯基化和酰化反应中，证明了各种路易斯酸对钯催化的C H活化的促进作用。通过研究不同的钯催化剂，芳族底物中的导向基团和通用的路易斯酸，研究了这种效应的普遍性。进行实验以监测反应并比较不同类型的路易斯酸的行为和活性。动力学研究揭示了确定C H活化步骤的速率，并进行了DFT研究以解释路易斯酸对C H活化的影响。