A novel strain of Actinomycetes was isolated from the body of an ant (Camponotus vagus Scopoli) and its genetic and morphological properties were characterized. The 16S rDNA gene sequence analysis of the isolate revealed its high phylogenetic relationship with type strains of Streptomyces violaceochromogenes NBRC 13100^T. As a result of antimicrobial activity assessment, it was found that the fermentation broth of the isolated strain both inhibited the growth and induced the SOS response in E. coli BW25113 ΔtolC strain cells. Using bioassay-guided fractionation, mass spectrometric and NMR analyses we identified the active compound to be nybomycin, a previously described antibiotic. Here we report for the first time Streptomyces producer of nybomycin in association with carpenter ants and demonstrate cytotoxic activity of nybomycin against human cell lines.

从蚂蚁体内分离出一种新的放线菌菌株（Camponotus vagus Scopoli），并对其遗传和形态特性进行了表征。该分离物的16S rDNA基因序列分析显示其与紫链霉菌NBRC 13100 ^T型菌株的系统发育关系。作为抗微生物活性评价的结果，发现分离株的发酵肉汤中都抑制生长和诱导SOS反应大肠杆菌BW25113 ΔtolC应变细胞。使用生物测定指导的分馏，质谱和NMR分析，我们确定了活性化合物为nybomycin，即先前描述的抗生素。在这里，我们首次报告木霉素与链霉素的链霉菌生产者，并证明了霉素对人细胞系的细胞毒活性。