Adenosine is a fascinating compound, crucial in many biochemical processes: this ubiquitous nucleoside serves as an essential building block of RNA, is also a component of ATP and regulates numerous pathophysiological mechanisms via binding to four extracellular receptors. Due to its hydrophilic nature, it belongs to a different world than lipids, and has no affinity for them. Since the 1970's, however, new discoveries have emerged and prompted the scientific community to associate adenosine with the lipid family, especially via liposomal preparations and bioconjugation. This seems to be an arranged marriage, but could it turn into a true love match? This review considered all types of unions established between adenosine and lipids. Even though exciting supramolecular structures were observed with adenosine-lipid conjugates, as well as with liposomal preparations which resulted in promising pre-clinical results, the translation of these technologies to the clinic is still limited.

腺苷是一种令人着迷的化合物，在许多生化过程中都至关重要：这种无处不在的核苷是RNA的基本组成部分，也是ATP的组成部分，并通过与四个细胞外受体结合来调节多种病理生理机制。由于其亲水性，它与脂质属于不同的世界，并且对脂质没有亲和力。但是，自1970年代以来，出现了新发现，并促使科学界特别是通过脂质体制剂和生物结合。这似乎是一场包办婚姻，但是它能变成一场真正的爱情配对吗？这项审查考虑了腺苷和脂质之间建立的所有类型的联合。尽管用腺苷-脂质缀合物以及脂质体制剂观察到令人兴奋的超分子结构，从而产生了可喜的临床前结果，但这些技术在临床上的应用仍然受到限制。