Polycaprolactone (PCL) is a bioresorbable and biocompatible polymer that has been widely used in long-term implants and controlled drug release applications. However, when it comes to tissue engineering, PCL suffers from some shortcomings such as slow degradation rate, poor mechanical properties, and low cell adhesion. The incorporation of calcium phosphate-based ceramics and bioactive glasses into PCL has yielded a class of hybrid biomaterials with remarkably improved mechanical properties, controllable degradation rates, and enhanced bioactivity that are suitable for bone tissue engineering. This review presents a comprehensive study on recent advances in the fabrication and properties of PCL-based composite scaffolds containing calcium phosphate-based ceramics and bioglasses in terms of porosity, degradation rate, mechanical properties, in vitro and in vivo biocompatibility and bioactivity for bone regeneration applications. The fabrication routes range from traditional methods such as solvent casting and particulate leaching to novel approaches including solid free-form techniques.

中文翻译：

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骨组织工程中含磷酸钙基陶瓷和生物活性玻璃的聚己内酯复合材料的制备与性能研究进展

聚己内酯（PCL）是一种可生物吸收和生物相容的聚合物，已广泛用于长期植入物和控制药物释放的应用中。但是，在组织工程方面，PCL存在一些缺点，例如降解速度慢，机械性能差和细胞粘附力低。将磷酸钙基陶瓷和生物活性玻璃结合到PCL中，产生了一类杂化生物材料，具有显着改善的机械性能，可控的降解速率和增强的生物活性，适用于骨组织工程。这篇综述对多孔性，降解率，机械性能，含磷钙基陶瓷和生物玻璃的基于PCL的复合支架的制备和性能进行了全面的研究。用于骨再生应用的体外和体内生物相容性和生物活性。制造路线从传统方法（例如溶剂浇铸和微粒浸出）到新颖的方法（包括固体自由成形技术）不等。