Measles vaccine and porcine myelin basic protein were both found to ameliorate or abolish the symptoms of adjuvant arthritis (AA) in Lewis rats whether inoculated at the time of adjuvant administration or after the onset of arthritis. These results are consistent with clinical observations that measles infection can sometimes cause remission of juvenile rheumatoid arthritis. The fact that measles virus proteins and myelin basic protein have significant regions of homology allowed peptides based on these regions to be synthesized. A twenty-amino acid sequence exhibits significant anti-arthritic activity when inoculated into rats with pre-existing AA and it also prevented onset of AA when a single dose was preinoculated three weeks prior to AA induction. These data suggest the possibility of developing novel therapeutic vaccines against some forms of arthritis.

无论在辅助给药时还是在关节炎发作后接种，Lewis大鼠中的麻疹疫苗和猪髓磷脂碱性蛋白均可改善或消除其佐剂性关节炎（AA）的症状。这些结果与临床观察结果一致，麻疹感染有时可导致青少年类风湿关节炎缓解。麻疹病毒蛋白和髓磷脂碱性蛋白具有重要的同源性这一事实，使得可以合成基于这些区域的肽。当将20个氨基酸的序列接种到预先存在AA的大鼠中时，它会显示出显着的抗关节炎活性，并且在诱导AA前三周预接种单剂时，它还可以防止AA的发作。