HIV envelope glycoprotein (Env) exhibits extreme antigenic variation that can be countered by an amazing class of immunoglobulins known as broadly neutralizing antibodies. Dingens et al. (2019) use saturating mutagenesis of Env to play out all of the potential bnAb escape strategies and in doing so define the functional epitopes of these important vaccine and immunotherapeutic targets.

中文翻译：

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与艾滋病下象棋

HIV包膜糖蛋白（Env）表现出极端的抗原变异，可以被称为广泛中和抗体的一类惊人的免疫球蛋白所抵消。Dingens等。（2019）使用Env的饱和诱变来发挥所有潜在的bnAb逃避策略，并以此定义这些重要疫苗和免疫治疗靶标的功能表位。