The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.

中文翻译：

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神经精神疾病中的泛素蛋白酶体途径。

泛素蛋白酶体系统（UPS）是高度保守的途径，可以严格调节细胞中的蛋白质更新。这个过程是神经元发育，分化和功能必不可少的。UPS的几名成员在神经精神疾病中受到干扰，突显了该途径在大脑发育和功能中的重要性。在这篇综述中，我们讨论了其中一些通路成员，它们调控的分子过程以及针对UPS的潜力，以努力开发神经精神病和神经发育障碍的治疗策略。