A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability†,Chemical Communications

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A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability†
Chemical Communications ( IF 4.3 ) Pub Date : 2019-02-15 00:00:00 , DOI: 10.1039/c8cc09964b
Hong-Guang Fu _{1,

2,

3,

4,

5} , Yong Chen _{1,

2,

3,

4,

5} , Qilin Yu _{1,

2,

3,

4,

5} , Yu Liu _{1,

2,

3,

4,

5}

Affiliation

Supramolecular assembly with tumor-targeting properties or photodynamic therapy (PDT) ability has recently become a focus of interest in biomaterial field because of its high therapeutic efficacy against tumor cells. Herein, we reported a new type of targeted supramolecular nanoparticles for photodynamic therapy of tumor cells constructed using adamantane-functionalized transferrin protein (Ad-TRF) and a β-cyclodextrin-functionalized ruthenium complex (Ru-HOP-CD), wherein Ad-TRFs acted as the targeted sites for tumor cells, the coordinated Ru(II) centers acted as the PDT active sites, and the biocompatible polysaccharide β-cyclodextrins acted as the non-covalent linkers. Significantly, the resultant Ru/polysaccharide/protein exhibited not only specific targeting properties towards tumor cells but also high PDT ability under the irradiation of visible light. Furthermore, the assembly showed selective killing towards tumor cells along with negligible toxicity towards normal cells.

中文翻译：

具有高光动力治疗能力的靶向肿瘤的Ru /多糖/蛋白质超分子组装体†

具有肿瘤靶向特性或光动力疗法（PDT）能力的超分子组装由于其对肿瘤细胞的高治疗功效，最近已成为生物材料领域的关注焦点。在本文中，我们报道了一种新型的靶向超分子纳米颗粒，用于使用金刚烷官能化的转铁蛋白（Ad-TRF）和β-环糊精官能化的钌复合物（Ru-HOP-CD）构建的肿瘤细胞的光动力治疗，其中Ad-TRFs充当肿瘤细胞的靶向位点，协调的Ru（II中心充当PDT的活性位点，而生物相容性多糖β-环糊精充当非共价接头。重要的是，所得的Ru /多糖/蛋白质不仅在可见光的照射下表现出对肿瘤细胞的特异性靶向特性，而且还表现出高PDT能力。此外，该组装物显示出对肿瘤细胞的选择性杀伤以及对正常细胞的可忽略的毒性。

更新日期：2019-02-15

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