Highly selective imaging of lysosomal azoreductase under hypoxia using pH-regulated and target-activated fluorescent nanoprobes,Chemical Communications

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Highly selective imaging of lysosomal azoreductase under hypoxia using pH-regulated and target-activated fluorescent nanoprobes
Chemical Communications ( IF 4.9 ) Pub Date : 2019-02-15 , DOI: 10.1039/c9cc00462a
Cong Zhu _{1,

2,

3} , Zhen Zou _{2,

3,

4} , Caixia Huang _{1,

2,

3} , Jing Zheng _{1,

2,

3} , Na Liu _{1,

2,

3} , Jishan Li _{1,

2,

3} , Ronghua Yang _{2,

3,

4}

Affiliation

In this work, we propose a pH-regulated and target-activated fluorescent nanoprobe for highly selective monitoring of lysosomal azoreductase under hypoxia in living cells. We expect it will offer a potentially rich opportunity to understand the physiological processes of lysosomes under hypoxic conditions.

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