Grow with the Flow: When Morphogenesis Meets Microfluidics,Advanced Materials

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Grow with the Flow: When Morphogenesis Meets Microfluidics
Advanced Materials ( IF 27.4 ) Pub Date : 2019-02-14 , DOI: 10.1002/adma.201805764
Pinak Samal ₁ , Clemens van Blitterswijk ₁ , Roman Truckenmüller ₁ , Stefan Giselbrecht ₁

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Developmental biology has advanced the understanding of the intricate and dynamic processes involved in the formation of an organism from a single cell. However, many gaps remain in the knowledge of embryonic development, especially regarding tissue morphogenesis. A possible approach to mimic such phenomena uses pluripotent stem cells in in vitro morphogenetic models. Herein, these systems are summarized with emphasis on the ability to better manipulate and control cellular interfaces with either liquid or solid materials using microengineered tools, which is critical for attaining deeper insights into pattern formation and stem cell differentiation during organogenesis. The role of conventional and customized cell‐culture systems in supporting important advances in the field of morphogenesis is discussed, and the fascinating role that material sciences and microengineering currently play and are expected to play in the future is highlighted. In conclusion, it is proffered that continued microfluidics innovations when applied to morphogenesis promise to provide important insights to advance many multidisciplinary fields, including regenerative medicine.

中文翻译：

随流量增长：当形态发生遇到微流体时

发育生物学已经使人们对从单个细胞形成生物体的复杂而动态的过程有了更深入的了解。然而，在胚胎发育的知识，特别是在组织形态发生方面，仍然存在许多空白。模仿这种现象的一种可能方法是在体外形态发生模型中使用多能干细胞。本文中，对这些系统进行了总结，重点在于使用微工程工具更好地控制和控制液体或固体材料与细胞界面的能力，这对于在器官发生过程中获得对模式形成和干细胞分化的深入了解至关重要。讨论了常规和定制的细胞培养系统在支持形态发生领域的重要进展中的作用，重点介绍了材料科学和微工程学目前正在发挥的，并有望在未来发挥的引人入胜的作用。总而言之，有人提出，当微流体学应用于形态发生方面的持续创新有望为推进包括再生医学在内的许多多学科领域提供重要的见识。

更新日期：2019-02-14

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