Concerns about vaccine safety can lead to decreased acceptance of vaccines and resurgence of vaccine-preventable diseases. We summarize the key evidence on some of the main current vaccine safety controversies in the United States, including (1) measles, mumps, and rubella vaccine and autism; (2) thimerosal, a mercury-based vaccine preservative and the risk of neurodevelopmental disorders; (3) vaccine-induced Guillain-Barré syndrome (GBS); (4) vaccine-induced autoimmune diseases; (5) safety of human papillomavirus vaccine; (6) aluminum adjuvant-induced autoimmune diseases and other disorders; and (7) too many vaccines given early in life predisposing children to health and developmental problems. A possible small increased risk of GBS following influenza vaccination has been identified, but the magnitude of the increase is less than the risk of GBS following influenza infection. Otherwise, the biological and epidemiologic evidence does not support any of the reviewed vaccine safety concerns.

中文翻译：

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美国疫苗安全的主要争议。

对疫苗安全性的担忧会导致对疫苗的接受程度下降以及疫苗可预防的疾病复燃。我们总结了有关美国当前一些主要疫苗安全性争议的关键证据，其中包括：（1）麻疹，腮腺炎，风疹疫苗和自闭症；（2）硫柳汞，一种基于汞的疫苗防腐剂，具有神经发育障碍的风险；（3）疫苗诱导的格林-巴利综合征（GBS）；（4）疫苗引起的自身免疫性疾病；（五）人乳头瘤病毒疫苗的安全性；（6）铝佐剂引起的自身免疫性疾病等；（7）生命早期给予的疫苗过多，使儿童容易遭受健康和发育问题的困扰。已确定在接种流感疫苗后GBS的风险可能会略有增加，但增加的幅度小于感染流感后发生GBS的风险。否则，生物学和流行病学证据不支持任何已审查的疫苗安全性问题。