The concept that mitochondria are highly dynamic is as widely accepted as it is untrue for a number of important contexts. Healthy mitochondria of the most energy-dependent and mitochondrial-rich mammalian organ, the heart, only rarely undergo fusion or fission and are seemingly static within cardiac myocytes. Here, we revisit mitochondrial dynamism with a fresh perspective developed from the recently discovered multifunctionality of mitochondrial fusion proteins and newly defined mechanisms for direct cross talk between mitochondrial dynamics, biogenesis, quality control, and trafficking pathways. Insights gained from comparing static mitochondrial biology in cardiac myocytes and dynamic mitochondrial biology in neurons are reviewed with the goal of understanding contextual fallacies of overly generalized characterizations of these essential and intriguing organelles.

中文翻译：

---

线粒体动力学的不断发展的概念。

线粒体具有高度动态性的概念已被广泛接受，因为它在许多重要环境中都是不正确的。线粒体是最依赖能量和线粒体最多的哺乳动物器官，心脏的健康线粒体很少发生融合或裂变，并且在心肌细胞内似乎是静止的。在这里，我们以从最近发现的线粒体融合蛋白的多功能性和新定义的线粒体动力学，生物发生，质量控制和运输途径之间的直接串扰机制发展的新视角重新审视线粒体动力学。