Oxidant molecules are produced in biological systems and historically have been considered causal mediators of damage and disease. While oxidants may contribute to the pathogenesis of disease, evidence continues to emerge that shows these species also play important regulatory roles in health. A major mechanism of oxidant sensing and signaling involves their reaction with reactive cysteine thiols within proteins, inducing oxidative posttranslational modifications that can couple to altered function to enable homeostatic regulation. Protein kinase A and protein kinase G are regulated by oxidants in this way, and this review focuses on our molecular-level understanding of these events and their role in regulating cardiovascular physiology during health and disease.

中文翻译：

---

基于半胱氨​​酸的氧化还原传感及其在心血管系统中依赖环核苷酸依赖性激酶的信号传导中的作用。

氧化剂分子是在生物系统中产生的，历史上一直被认为是损害和疾病的因果介体。尽管氧化剂可能是疾病的发病机理，但仍在继续出现证据，表明这些物种在健康中也起着重要的调节作用。氧化剂感测和信号转导的主要机制涉及它们与蛋白质中的反应性半胱氨酸硫醇的反应，诱导氧化后翻译修饰，该修饰可与功能改变耦合以实现稳态调节。蛋白质激酶A和蛋白质激酶G通过这种方式被氧化剂调节，并且本文的重点是我们对这些事件的分子水平的理解以及它们在健康和疾病期间调节心血管生理的作用。