Ca2+- and voltage-gated K+ channels of large conductance (BK channels) are expressed in a diverse variety of both excitable and inexcitable cells, with functional properties presumably uniquely calibrated for the cells in which they are found. Although some diversity in BK channel function, localization, and regulation apparently arises from cell-specific alternative splice variants of the single pore-forming α subunit ( KCa1.1, Kcnma1, Slo1) gene, two families of regulatory subunits, β and γ, define BK channels that span a diverse range of functional properties. We are just beginning to unravel the cell-specific, physiological roles served by BK channels of different subunit composition.

中文翻译：

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Beta和Gamma亚基调节BK通道。

大电导的Ca2 +和电压门控K +通道（BK通道）在各种类型的可兴奋和不可兴奋的细胞中表达，其功能特性可能是针对发现它们的细胞进行了唯一校准的。虽然BK通道功能，定位和调节的某些多样性显然是由单个成孔α亚基（KCa1.1，Kcnma1，Slo1）基因，两个调节亚基家族β和γ的细胞特异性替代剪接变体引起的，定义跨越各种功能特性的BK渠道。我们才刚刚开始揭示由不同亚基组成的BK通道发挥的细胞特异性生理作用。