Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; however, new modalities of caspase-independent regulated cell death have been identified, including necroptosis, pyroptosis, and autophagic cell death. As an understanding of the cellular mechanisms that mediate regulated cell death continues to grow, there is increasing evidence that these pathways are implicated in the pathogenesis of many pulmonary disorders. This review summarizes our understanding of regulated cell death as it pertains to the pathogenesis of chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and pulmonary arterial hypertension.

中文翻译：

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肺细胞死亡：细胞凋亡-坏死性轴。

调节细胞死亡是消除受损，感染或多余细胞的主要机制。以前，凋亡被认为是唯一受调节的细胞死亡机制。然而，已经确定了不依赖半胱天冬酶的调控细胞死亡的新形式，包括坏死性坏死病，细胞凋亡和自噬性细胞死亡。随着对调节受调节的细胞死亡的细胞机制的了解不断增长，越来越多的证据表明这些途径与许多肺部疾病的发病机制有关。这篇综述总结了我们对调节性细胞死亡的理解，因为它涉及慢性阻塞性肺疾病，哮喘，特发性肺纤维化，急性呼吸窘迫综合征和肺动脉高压的发病机理。