Endothelial cell (EC) metabolism is important for health and disease. Metabolic pathways, such as glycolysis, fatty acid oxidation, and amino acid metabolism, determine vasculature formation. These metabolic pathways have different roles in securing the production of energy and biomass and the maintenance of redox homeostasis in vascular migratory tip cells, proliferating stalk cells, and quiescent phalanx cells, respectively. Emerging evidence demonstrates that perturbation of EC metabolism results in EC dysfunction and vascular pathologies. Here, we summarize recent insights into EC metabolic pathways and their deregulation in vascular diseases. We further discuss the therapeutic implications of targeting EC metabolism in various pathologies.

中文翻译：

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代谢途径为内皮细胞驱动提供了动力。

内皮细胞（EC）的代谢对于健康和疾病很重要。代谢途径，例如糖酵解，脂肪酸氧化和氨基酸代谢，决定了脉管系统的形成。这些新陈代谢途径分别在确保能量和生物质的产生以及维持血管迁移性尖端细胞，增生的茎细胞和静态指骨细胞中的氧化还原稳态中起着不同的作用。越来越多的证据表明，EC代谢紊乱会导致EC功能障碍和血管病变。在这里，我们总结了有关EC代谢途径及其在血管疾病中的失调的最新见解。我们进一步讨论了在各种病理学中靶向EC代谢的治疗意义。