Research over the last decades has provided strong evidence for the pivotal role of the tumor-associated blood and lymphatic vasculature in supporting immunoevasion and in subverting T cell-mediated immunosurveillance. Conversely, tumor blood and lymphatic vessel growth is in part regulated by the immune system, with infiltrating innate as well as adaptive immune cells providing both immunosuppressive and various angiogenic signals. Thus, tumor angiogenesis and escape of immunosurveillance are two cancer hallmarks that are tightly linked and interregulated by cell constituents from compartments secreting both chemokines and cytokines. In this review, we discuss the implication and regulation of innate and adaptive immune cells in regulating blood and lymphatic angiogenesis in tumor progression and metastases. Moreover, we also highlight novel therapeutic approaches that target the tumor vasculature as well as the immune compartment to sustain and improve therapeutic efficacy in cancer.

中文翻译：

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肿瘤和转移中免疫细胞对血液和淋巴管的调节。


过去几十年的研究为肿瘤相关血液和淋巴管系统在支持免疫逃避和破坏 T 细胞介导的免疫监视方面的关键作用提供了强有力的证据。相反，肿瘤血液和淋巴管的生长部分受到免疫系统的调节，浸润的先天性和适应性免疫细胞提供免疫抑制和各种血管生成信号。因此，肿瘤血管生成和免疫监视的逃避是两个癌症标志，它们与分泌趋化因子和细胞因子的区室的细胞成分紧密相连并相互调节。在这篇综述中，我们讨论了先天性和适应性免疫细胞在调节肿瘤进展和转移中血液和淋巴管生成中的意义和调节。此外，我们还重点介绍了针对肿瘤脉管系统和免疫区室的新颖治疗方法，以维持和提高癌症治疗效果。