Physical inactivity is one of the leading health problems in the world. Strong epidemiological and clinical evidence demonstrates that exercise decreases the risk of more than 35 different disorders and that exercise should be prescribed as medicine for many chronic diseases. The physiology and molecular biology of exercise suggests that exercise activates multiple signaling pathways of major health importance. An anti-inflammatory environment is produced with each bout of exercise, and long-term anti-inflammatory effects are mediated via an effect on abdominal adiposity. There is, however, a need to close the gap between knowledge and practice and assure that basic research is translated, implemented, and anchored in society, leading to change of praxis and political statements. In order to make more people move, we need a true translational perspective on exercise as medicine, from molecular and physiological events to infrastructure and architecture, with direct implications for clinical practice and public health.

中文翻译：

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以运动为医学重点的优化健康的生理学。

缺乏运动是世界上主要的健康问题之一。强大的流行病学和临床证据表明，运动可降低超过35种不同疾病的风险，应将运动处方为许多慢性疾病的药物。运动的生理学和分子生物学表明，运动可以激活具有重要健康意义的多种信号通路。每次运动都会产生抗炎环境，并且通过对腹部肥胖的影响来介导长期的抗炎作用。但是，需要缩小知识与实践之间的鸿沟，并确保基础研究的翻译，实施和扎根于社会，从而导致实践和政治言论的变化。为了让更多的人移动，