Abstract In this work, an inorganic-salt coprecipitation route was used to synthesize nanostructured diopside (CaMgSi2O6) powders without/with 2 mol% strontium substituted for calcium. A sponge replication technique was then employed on the powders to manufacture highly porous scaffolds with pore interconnectivity. The structure, bioactivity, biodegradation and cell adhesion of the samples were studied by X-ray diffraction, Fourier-transform infrared spectroscopy, field-emission scanning electron microscopy/energy-dispersive X-ray spectroscopy, Archimedes densitometry, and inductively coupled plasma spectroscopy analyses. According to the results, the Sr-doping process improves the sinterability and apatite-formation ability of the diopside-based scaffolds, but retards their biodegradation. Mesenchymal stem cells also present better adhesion and spreading with typical cell extensions on the Sr-doped scaffold in comparison to the pure one. It is eventually concluded that strontium can be further considered as a doping agent to improve the bioactivity and biocompatibility of Mg-Ca silicate scaffolds.

中文翻译：

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锶掺杂到透辉石组织工程支架中

摘要 在这项工作中，采用无机盐共沉淀法合成了不含/含 2 mol% 锶替代钙的纳米结构透辉石 (CaMgSi2O6) 粉末。然后在粉末上采用海绵复制技术来制造具有孔互连性的高度多孔支架。通过X射线衍射、傅里叶变换红外光谱、场发射扫描电子显微镜/能量色散X射线光谱、阿基米德密度计和电感耦合等离子体光谱分析研究了样品的结构、生物活性、生物降解和细胞粘附. 根据结果​​，Sr 掺杂工艺提高了透辉石基支架的烧结性和磷灰石形成能力，但阻碍了它们的生物降解。与纯细胞相比，间充质干细胞在 Sr 掺杂支架上的典型细胞延伸也表现出更好的粘附和扩散。最终得出结论，锶可以进一步被认为是一种掺杂剂，以提高镁钙硅酸盐支架的生物活性和生物相容性。