Objective

The Avon Longitudinal Study of Parents and Children (ALSPAC) and Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) cohorts were used to determine whether repeated exposure to gastroenteritis in early life could predict risk for psychiatric problems in childhood and in ALSPAC adolescents. We determined whether inflammatory biomarkers moderated the association between repeated gastroenteritis and mental health in adolescents from ALSPAC.

Method

Episodes of gastroenteritis from birth to 30 and 36 months were reported by mothers. Psychological problems were assessed using the total difficulties and subscale scores on the Revised Rutter Parent Scale for Preschool Children at 42 months and the Strengths and Difficulties Questionnaire (SDQ) at 81 months in ALSPAC. Presence of psychiatric disorders at 15.5 years was assessed using the Development and Well-Being Assessment (DAWBA) in ALSPAC. In the MAVAN replication cohort, total difficulties were assessed on the SDQ at 60 and 72 months. Serum interleukin-6 (IL-6) and C-reactive protein (CRP) at 9.5 years and CRP at 15.5 years were measured in ALSPAC participants.

Results

Repeated gastroenteritis associated with the total difficulties score in ALSPAC and MAVAN children. The β values were small, indicating that the clinical relevance of these findings requires further investigation. Repeated gastroenteritis was significantly associated with an increased prevalence of externalizing disorders at age 15.5 years, but odds ratios were small. CRP or IL-6 at 9.5 years or CRP at 15.5 years did not significantly moderate the association between repeated gastroenteritis and prevalence of psychiatric disorders.

Conclusion

Identifying factors associated with vulnerability to psychopathology is key to early identification of individuals at risk.

中文翻译：

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胃肠炎的反复发作与儿童期和青春期的心理健康问题之间的关联。

客观的

父母和儿童的雅芳纵向研究（ALSPAC）和母亲的逆境，脆弱性和神经发育（MAVAN）队列用于确定早年反复接触肠胃炎是否可以预测儿童和ALSPAC青少年的精神疾病风险。我们确定了炎症生物标记物是否能缓解ALSPAC青少年的反复胃肠炎和心理健康之间的联系。

方法

母亲报告了从出生到30和36个月的胃肠炎发作。使用修订后的42个月学龄前儿童Rutter父母量表和81个月的ALSPAC中的优势与困难问卷（SDQ）评估总的心理困难和子量表得分。使用ALSPAC中的发展和幸福感评估（DAWBA）评估了15.5岁时精神疾病的存在。在MAVAN复制队列中，在60个月和72个月时在SDQ上评估了总困难。在ALSPAC参与者中测量了9.5岁时的血清白细胞介素6（IL-6）和C反应蛋白（CRP），以及15.5岁时的CRP。

结果

ALSPAC和MAVAN儿童的反复胃肠炎与总困难评分相关。β值很小，表明这些发现的临床相关性需要进一步研究。反复的肠胃炎与15.5岁时外在性疾病的患病率增加显着相关，但是优势比很小。9.5岁时的CRP或IL-6或15.5岁时的CRP并未显着缓解反复的胃肠炎与精神疾病患病率之间的关联。

结论

识别与精神病理学易感性相关的因素是及早识别有风险个体的关键。