Oxidative stress has been reported to increase with aging, and although several age-related changes in redox parameters have been described, none of them have been verified as markers of the rate of aging and life span. Therefore, antioxidant (catalase, glutathione peroxidase, reductase activities, and reduced glutathione) and oxidant (oxidized glutathione, basal superoxide anion, and malondialdehyde concentrations) parameters were studied in whole blood cells from humans divided into different age groups (adult, mature, older adult, nonagenarian, and centenarian) in a cross-sectional study. Moreover, the same parameters were investigated in peritoneal leukocytes of mice at the analogous human ages (adult, mature, old, very old, and long-lived) in a longitudinal study as well as in adult prematurely aging mice. The results reveal that the age-related alterations of these markers are similar in humans and mice, with decreased antioxidants and increased oxidants in old participants, whereas long-lived individuals show similar values to those in adults. In addition, adult prematurely aging mice showed similar values to those in chronologically old mice and had a shorter life span than nonprematurely aging mice. Thus, these parameters could be proposed as markers of the rate of aging and used to ascertain biological age in humans.

中文翻译：

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氧化还原参数作为老化率的标志物和寿命预测因子

据报道，氧化应激会随着年龄的增长而增加，尽管已描述了氧化还原参数的几种与年龄相关的变化，但没有一个被证实是衰老速率和寿命的标志。因此，研究人员在分为不同年龄组（成人，成熟，老年人）的人全血细胞中研究了抗氧化剂（过氧化氢酶，谷胱甘肽过氧化物酶，还原酶活性和还原型谷胱甘肽）和氧化剂（氧化型谷胱甘肽，基础超氧化物阴离子和丙二醛浓度）参数。成人，nonagenarian和百岁老人）的横断面研究。此外，在纵向研究中，在类似人类年龄（成年，成熟，老，非常老和长寿）的小鼠的腹膜白细胞以及成年的早衰小鼠中研究了相同的参数。结果表明，这些标记物的年龄相关变化在人和小鼠中相似，在老年参与者中抗氧化剂减少，氧化剂增加，而长寿个体显示与成年人相似的值。此外，成年的早衰小鼠与按时间顺序的老小鼠表现出相似的值，并且寿命比未早衰的小鼠要短。因此，这些参数可以被提议作为衰老速度的标志，并可以用来确定人类的生物学年龄。成年的早衰小鼠显示出与按时间顺序的老小鼠相似的值，并且寿命比未早衰的小鼠短。因此，这些参数可以被提议作为衰老速度的标志，并可以用来确定人类的生物学年龄。成年的早衰小鼠显示出与按时间顺序的老小鼠相似的值，并且寿命比未早衰的小鼠短。因此，这些参数可以被提议作为衰老速度的标志，并可以用来确定人类的生物学年龄。