Epigenetic abnormalities and aberrant expression of non-coding RNAs are two emerging features of cancer cells, both of which are responsible for deregulated gene expression. In this review, we describe the interplay between the two. Specific themes include epigenetic silencing of tumor suppressor miRNAs, epigenetic activation of oncogenic miRNAs, epigenetic aberrations caused by miRNAs, and naturally occurring compounds which modulate miRNA expression through epigenetic mechanisms.

中文翻译：

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表观遗传异常与微小RNA表达失调之间的相互作用

表观遗传异常和非编码RNA的异常表达是癌细胞的两个新出现的特征，这两者都是导致基因表达失调的原因。在这篇评论中，我们描述了两者之间的相互作用。具体主题包括肿瘤抑制miRNA的表观遗传沉默，致癌miRNA的表观遗传激活，miRNA引起的表观遗传畸变以及通过表观遗传机制调节miRNA表达的天然化合物。