Five undescribed diterpenoid alkaloids tanguticulines A-E and two undescribed amide compounds 5-methoxy-N-Salicylanthranilic acid methyl ester and 3, 5-dimethoxy-4- hydroxycinnamamide-4-O-β-D-glucopyranoside, were isolated from the whole plant of Aconitum tanguticum (Maxim.) Stapf. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. Compounds 1 and 5 were evaluated for their antivirus activities against influenza a (H1N1) virus in vitro. Both of them showed obvious inhibitory effect on the cytopathic changes induced by H1N1, with IC50 values of 2.9 μg mL-1 and 2.4 μg mL-1, respectively.

中文翻译：

---

来自乌头 (Maxim.) Stapf 全株的二萜生物碱

从乌头全株中分离出五种未描述的二萜生物碱 tanguticulines AE 和两种未描述的酰胺化合物 5-甲氧基-N-水杨酸甲酯和 3, 5-二甲氧基-4-羟基肉桂酰胺-4-O-β-D-吡喃葡萄糖苷tanguticum (Maxim.) Stapf. 它们的结构是通过对 MS 和 NMR 光谱数据的详细分析来确定的。在体外评估了化合物 1 和 5 对甲型流感 (H1N1) 病毒的抗病毒活性。两者对H1N1引起的细胞病变均有明显抑制作用，IC50值分别为2.9 μg mL-1和2.4 μg mL-1。