The analytical quantification and follow-up of the hormone prolactin is very important in clinical diagnosis (e.g., in cases of breast cancer), treatment, and the medical laboratory. The development of a new simple, fast, and less costly method is of considerable importance. Novel praseodymium metal–organic framework nanofibers (Pr-MOF-NFs) were synthesized by a facile and simple method for the determination of human prolactin in serum samples. The Pr-MOF-NFs were well characterized with several spectroscopic tools, such as mass spectrometry, Fourier transform IR spectroscopy, UV–vis spectroscopy, elemental analysis, X-ray diffraction, field-emission scanning electron microscopy combined with energy-dispersive X-ray spectroscopy, and high-resolution transmission electron microscopy. The photoluminescence of Pr-MOF-NFs was investigated, and the results revealed that Pr-MOF-NFs could be used as a sensitive and selective nanofiber optical sensor for the detection of human prolactin. The calibration graph was studied over a wide prolactin concentration range of 0–200 ng/mL, with limits of detection and quantitation of 0.276 and 0.838 ng/mL, respectively, lower than the values mentioned in previous reports. The correlation coefficient was 0.9792. Moreover, the Pr-MOF-NFs were applied successfully for the detection of serum human prolactin at clinically applicable concentrations without interference from several types of hormones and various interfering analytes.

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催乳激素的分析定量和随访在临床诊断（例如乳腺癌），治疗和医学实验室中非常重要。开发一种新的简单，快速且成本较低的方法非常重要。新型的simple金属-有机骨架纳米纤维（Pr-MOF-NFs）是通过一种简便而简便的方法测定血清样品中人催乳素的方法而合成的。Pr-MOF-NFs的质谱仪，质谱，傅立叶变换红外光谱，紫外-可见光谱，元素分析，X射线衍射，场发射扫描电子显微镜结合能量色散X-射线光谱仪等多种光谱工具已得到很好的表征。射线光谱学和高分辨率透射电子显微镜。研究了Pr-MOF-NFs的光致发光，结果表明，Pr-MOF-NFs可以用作检测人催乳素的灵敏和选择性的纳米纤维光学传感器。在0-200 ng / mL的广泛催乳素浓度范围内研究了校准图，其检出限和定量限分别为0.276和0.838 ng / mL，低于先前报告中提到的值。相关系数为0.9992。此外，Pr-MOF-NFs已成功用于临床可检测浓度的血清人催乳素检测，而不受几种激素和各种干扰分析物的干扰。的检出限和定量限分别为0.276和0.838 ng / mL，低于先前报告中提到的值。相关系数为0.9992。此外，Pr-MOF-NFs已成功应用于临床适用浓度的血清人催乳素的检测，而不受几种激素和各种干扰分析物的干扰。的检出限和定量限分别为0.276和0.838 ng / mL，低于先前报告中提到的值。相关系数为0.9992。此外，Pr-MOF-NFs已成功应用于临床适用浓度的血清人催乳素的检测，而不受几种激素和各种干扰分析物的干扰。

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