Pancreatic cancer characteristically has an extremely dense stroma, which facilitates chemoresistance by creating physical and biological barriers to therapeutic agents. Thus, stroma-depleting agents may enhance the delivery and efficacy of chemotherapy drugs. However, stroma-targeting therapy for pancreatic cancer is a double-edged sword, as the stroma can also inhibit tumor metastasis and malignancy. In-depth understanding of the critical role of the stroma in cancer metastasis may improve therapeutic approaches by allowing them to harness specific features of the stroma to treat pancreatic cancer.

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关于胰腺癌肿瘤基质耗竭的思考

胰腺癌的特征是具有非常致密的基质，其通过对治疗剂产生物理和生物屏障来促进化学抗性。因此，基质消耗剂可以增强化学治疗药物的递送和功效。然而，针对胰腺癌的针对基质的疗法是一把双刃剑，因为基质还可以抑制肿瘤转移和恶性肿瘤。深入了解基质在癌症转移中的关键作用可能会通过允许它们利用基质的特定特征来治疗胰腺癌来改善治疗方法。