Overall and subgroup prevalence of pyoderma gangrenosum among patients with hidradenitis suppurativa: A population-based analysis in the United States,Journal of the American Academy of Dermatology

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Overall and subgroup prevalence of pyoderma gangrenosum among patients with hidradenitis suppurativa: A population-based analysis in the United States
Journal of the American Academy of Dermatology ( IF 12.8 ) Pub Date : 2019-02-07 , DOI: 10.1016/j.jaad.2019.02.004
Rachel Tannenbaum , Andrew Strunk , Amit Garg

Background

Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are reported to coexist, although the prevalence of PG among patients with HS has not been systematically evaluated.

Objective

To evaluate PG prevalence among patients with HS.

Methods

Cross-sectional analysis of adults with PG among patients with HS and patients without HS through use of electronic health records data from a population-based sample of 55 million patients.

Results

The prevalence of PG among 68,232 patients with HS was 0.18% (125 of 68,232), compared with 0.01% (1835 of 31,435,166) among those without HS (P < .0001). Prevalence was markedly higher among patients with HS and Crohn's disease (CD) (3.68%) than among patients with HS but without CD (0.12%). The odds of having PG were 21.14 (95% confidence interval [CI], 17.51-25.51) times greater among patients with HS than among those without HS. Patients with HS with CD had 12.38 (95% CI, 9.15-16.74) times the odds of having PG than did patients without HS but with CD. Among patients without CD, compared with patients without HS, those with HS had 26.51 (95% CI, 21.07-33.36) times the odds of having PG.

Limitations

We could not establish HS phenotype among those having coexistent PG, nor could we distinguish syndromic from nonsyndromic cases.

Conclusion

Patients with HS have an increased prevalence of PG, regardless of CD status. Painful ulcerations among patients with HS warrant additional evaluation for PG.

中文翻译：

化脓性汗腺炎患者中坏疽性脓皮病的总体和亚组患病率：美国一项基于人群的分析

背景

尽管尚未系统评估HS患者中PG的患病率，但有化脓性汗腺炎（HS）和坏疽性脓皮病（PG）并存。

客观的

为了评估HS患者中的PG患病率。

方法

通过使用电子健康记录数据（来自5500万患者的基于人群的样本）对有HS的患者和无HS的患者中的PG成人进行横断面分析。

结果

68,232例HS患者中PG的患病率为0.18％（68,232中的125），而无HS患者中PG的患病率为0.01％（31,435,166中的1835）（P <.0001）。HS和克罗恩病（CD）患者的患病率（3.68％）明显高于没有CD的HS患者（0.12％）。HS患者中有PG的几率是无HS患者的21.14倍（95％置信区间[CI]，17.51-25.51）倍。患有CD的HS患者与没有CD的HS患者相比，发生PG的几率是未患HS的患者的12.38倍（95％CI，9.15-16.74）。在没有CD的患者中，与没有HS的患者相比，具有HS的患者的26.51（95％CI，21.07-33.36）倍于PG的几率。