Necroptosis is a programmed, caspase-independent cell death that is morphologically similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by releasing damage-associated molecular patterns. Recent studies suggest that tumor undergoes necroptosis in vivo and necroptosis has pro- or anti-tumoral effects in cancer development and progression. Furthermore, triggering necroptosis in tumor cells has been explored as a potential therapeutic strategy against cancer. Here, we will review the recent research progress of necroptosis in conferring anti- or pro-tumoral effects and its potential application in cancer therapy.

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坏死病在癌症中的作用：一把双刃剑？

坏死性坏死是程序性的，不依赖胱天蛋白酶的细胞死亡，在形态学上类似于坏死。不同于凋亡，坏死病通过释放与损伤相关的分子模式而引起炎症反应。最近的研究表明，肿瘤在体内发生坏死性坏死，而坏死性坏死在癌症的发生和发展中具有前肿瘤作用或抗肿瘤作用。此外，已经探索了触发肿瘤细胞中的坏死病作为抗癌的潜在治疗策略。在这里，我们将回顾坏死病在赋予抗肿瘤或促肿瘤作用方面的最新研究进展及其在癌症治疗中的潜在应用。