We reported a facile and efficient catalytic system, involving Cu powder and n-butylamine, for oxidative coupling of terminal alkynes under ambient conditions. Various terminal alkynes can be converted into corresponding symmetrical and unsymmetrical 1,4-disubstituted 1,3-diynes bearing a broad range of functional groups. This protocol can be accomplished in a one-pot process using air as environmentally friendly oxidant at room temperature and amenable to gram-scale synthesis.

中文翻译：

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铜粉/正丁胺：在环境条件下末端炔的均相和交叉偶联的有效催化体系

我们报道了一种简便有效的催化体系，包括铜粉和正丁胺，用于环境条件下末端炔烃的氧化偶联。各种末端炔烃可以转化为带有广泛官能团的相应的对称和不对称的1,4-二取代的1,3-二炔。该方案可以在室温下使用空气作为环境友好型氧化剂并适合克级合成的一锅法过程中完成。