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In vitro protective effects of botryosphaeran, a (1-->3;1-->6)-beta-d-glucan, against mutagens in normal and tumor rodent cells.
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ( IF 2.3 ) Pub Date : 2017 Feb , DOI: 10.1016/j.mrgentox.2016.12.003 Leandra E Kerche-Silva 1 , Ilce M S Cólus 2 , Maressa Malini 2 , Mateus Prates Mori 2 , Robert F H Dekker 3 , Aneli M Barbosa-Dekker 1
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ( IF 2.3 ) Pub Date : 2017 Feb , DOI: 10.1016/j.mrgentox.2016.12.003 Leandra E Kerche-Silva 1 , Ilce M S Cólus 2 , Maressa Malini 2 , Mateus Prates Mori 2 , Robert F H Dekker 3 , Aneli M Barbosa-Dekker 1
Affiliation
Botryosphaeran (BOT) is an exocellular beta-d-glucan (carbohydrate biopolymer) of the (1-->3;1-->6)-linked type produced by Botryosphaeria rhodina MAMB-05. The cytotoxic, mutagenic, genotoxic, and protective effects of this substance were evaluated in Chinese hamster lung fibroblasts (V79) and rat hepatocarcinoma cells (HTC) by the micronucleus test (MN) and the comet assay. BOT was not genotoxic in either cell line; it decreased the clastogenic effects of doxorubicin, H2O2, and benzo[a]pyrene. These results indicate that BOT may have potential as a therapeutic agent.
更新日期：2017-01-31
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