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Genomic Hallmarks of Thyroid Neoplasia
Annual Review of Pathology: Mechanisms of Disease ( IF 28.4 ) Pub Date : 2018-01-24 00:00:00 , DOI: 10.1146/annurev-pathol-121808-102139
Thomas J. Giordano 1
Affiliation  

The genomic landscape of thyroid cancers that are derived from follicular cells has been substantially elucidated through the coordinated application of high-throughput genomic technologies. Here, I review the common genetic alterations across the spectrum of thyroid neoplasia and present the resulting model of thyroid cancer initiation and progression. This model illustrates the striking correlation between tumor differentiation and overall somatic mutational burden, which also likely explains the highly variable clinical behavior and outcome of patients with thyroid cancers. These advances are yielding critical insights into thyroid cancer pathogenesis, which are being leveraged for the development of new diagnostic tools, prognostic and predictive biomarkers, and novel therapeutic approaches.

中文翻译:


甲状腺肿瘤的基因组特征

通过高通量基因组技术的协同应用,已经充分阐明了来源于滤泡细胞的甲状腺癌的基因组格局。在这里,我回顾了甲状腺肿瘤形成过程中常见的遗传改变,并提出了甲状腺癌发生和发展的结果模型。该模型说明了肿瘤分化与总体体细胞突变负担之间的惊人相关性,这也可能解释了甲状腺癌患者的高度可变的临床行为和预后。这些进展对甲状腺癌的发病机理产生了重要的见解,这些见解被用于开发新的诊断工具,预后和预测性生物标志物以及新颖的治疗方法。

更新日期:2018-01-24
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