Polyprenol isolated from spruce needles was subjected to phosphorylation and acylation. Its phosphorylation with hexaethylphosphorous triamide in dioxane afforded bis(polyprenyl) N,N-diethylphosphoramidite which was hydrolyzed to bis(polyprenyl) phosphonate. The latter can be used in the synthesis of prodrugs. The acylation of polyprenol with aromatic and heterocyclic carboxylic acid chlorides gave the corresponding esters as potential precursors of pharmacologically important compounds. The structure of the isolated compounds was confirmed by ¹H, ³¹P, and ¹³C NMR and IR spectra.

中文翻译：

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通过磷酸化和酰化改性聚丙烯酸酯

从云杉针中分离出的聚戊二烯进行磷酸化和酰化。用六乙基亚磷酸三酰胺在二恶烷中将其磷酸化，得到双（聚异戊二烯）N，N-二乙基亚磷酰胺，其水解为双（聚异戊二烯）膦酸酯。后者可用于前药的合成。聚丙烯酸酯与芳香族和杂环羧酸氯化物的酰化反应使相应的酯成为具有重要药理作用的化合物的潜在前体。分离的化合物的结构通过¹ H，³¹ P和¹³ C NMR和IR光谱确认。