The ability of skin to act as a barrier is primarily determined by cells that maintain the continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult mammals is a complex multi-step process that involves overlapping stages of blood clot formation, inflammation, re-epithelialization, granulation tissue formation, neovascularization, and remodeling. Under favorable conditions, epidermal regeneration begins within hours after injury and takes several days until the epithelial surface is intact due to reorganization of the basement membrane. Regeneration relies on numerous signaling cues and on multiple cellular processes that take place both within the epidermis and in other participating tissues. A variety of modulators are involved, including growth factors, cytokines, matrix metalloproteinases, cellular receptors, and extracellular matrix components. Here we focus on the involvement of the extracellular matrix proteins that impact epidermal regeneration during wound healing.

皮肤充当屏障的能力主要由维持皮肤连续性和完整性并在受伤后恢复的细胞决定。成年哺乳动物的皮肤伤口愈合是一个复杂的多步骤过程，涉及血凝块形成，炎症，再上皮形成，肉芽组织形成，新血管形成和重塑的重叠阶段。在有利的条件下，表皮再生在受伤后数小时内开始，需要几天，直到由于基膜的重组而使上皮表面完好无损。再生依赖于表皮和其他参与组织中发生的多种信号提示和多种细胞过程。涉及多种调节剂，包括生长因子，细胞因子，基质金属蛋白酶，细胞受体和细胞外基质成分。在这里，我们专注于影响伤口愈合过程中表皮再生的细胞外基质蛋白的参与。