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The malignant niche: safe spaces for toxic stem cell marketing
npj Regenerative Medicine ( IF 6.4 ) Pub Date : 2017-12-19 , DOI: 10.1038/s41536-017-0036-x
Douglas Sipp

Many tumors are sustained by microenvironments, or niches, that support and protect malignant cells, thus conferring a competitive advantage against both healthy cells and therapeutic interventions (for a brief review, see Yao and Link (Stem Cells 35: 3–8, 2017)). The global industry engaged in the commercial promotion of unproven and scientifically implausible cell-based “regenerative” therapies has developed a number of self-protective strategies that support its survival and growth in ways that are broadly analogous to the functions of the malignant niche.



中文翻译:

恶性生态位:有毒干细胞营销的安全空间

许多肿瘤由支持和保护恶性细胞的微环境或生态位所维持,因此赋予了对抗健康细胞和治疗干预的竞争​​优势(简要回顾,请参见Yao和Link(干细胞,35:3-8,2017年) )。从事未经证实且科学上难以置信的基于细胞的“再生”疗法的商业推广的全球行业,已经开发出多种自我保护策略,以与恶性小生境的功能大致相似的方式支持其生存和生长。

更新日期:2019-11-18
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