Persons with Mild Cognitive Impairment (MCI) are at high Alzheimer’s Disease (AD) risk but the development of sensitive measures to assess subtle cognitive decline in this population poses a major challenge for clinicians and researchers. Eye movement monitoring is a non-invasive, sensitive way to assess subtle cognitive processes in clinical populations. We conducted a critical review and a meta-analysis of the literature on pro and antisaccade paradigm in AD/MCI. The meta-analysis included 20 studies, all of which used the prosaccade paradigm and 13 of which studied the antisaccade paradigm as well. Our meta-analysis showed that AD but not MCI patients showed longer prosaccade latencies when compared to controls. While antisaccade latencies did not differentiate between patients from controls, antisaccade error rate were significantly increased among patients in comparison to controls in over 87% of the studies. These findings highlight antisaccade error rate as a reliable tool to distinguish inhibition abilities between AD/MCI and healthy older persons.

中文翻译：

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阿尔茨海默氏病患者的前扫盲和反扫盲范例：荟萃分析

患有轻度认知障碍（MCI）的人处于阿尔茨海默氏病（AD）的高风险中，但是开发评估该人群中微妙的认知能力下降的敏感措施对临床医生和研究人员提出了重大挑战。眼动监测是一种无创，敏感的方法，可以评估临床人群中的细微认知过程。我们对AD / MCI中的前扫视范式和反扫视范式的文献进行了严格的审查和荟萃分析。荟萃分析包括20项研究，所有研究都使用了旁通范式，还有13项还研究了反旁通范式。我们的荟萃分析显示，与对照组相比，AD而非MCI患者表现出更长的潜伏潜伏期。尽管抗扫视潜伏期不能区分患者和对照组，在超过87％的研究中，与对照组相比，患者的抗扫视错误率显着提高。这些发现强调了抗扫视错误率是区分AD / MCI与健康老年人之间抑制能力的可靠工具。