Poly(N-isopropylacrylamide)-based microgel clusters were successfully prepared using polymersomes as “microreactors”, which were fabricated through microfluidics. The clusters were formed from the cross-linking reaction between ruthenium/amino group dual functionalized poly(N-isopropylacrylamide) microgels and linear poly(N-isopropylacrylamide)-r-(N-acryloxysuccinimide)-based polymer linkers under neutral pH conditions. By simply adjusting the ratio of N-isopropylacrylamide to N-acryloxysuccinimide in the polymer cross-linkers, the internal structures of the clusters can be controlled; hence, the temperature response of the clusters can be regulated. It was demonstrated that these different microgel clusters showed various degrees of chemomechanical oscillations when the clusters were exposed to a catalyst-free solution containing Belousov–Zhabotinsky reaction substrates.

中文翻译：

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使用聚合物囊泡作为“微反应器”的具有定制的温度响应特性的自激微凝胶团簇的微流体制备

使用聚合物囊泡作为“微反应器”，成功地制备了基于聚（N-异丙基丙烯酰胺）的微凝胶团簇，该微囊团是通过微流控技术制备的。簇是在中性pH条件下，由钌/氨基双官能化聚N-异丙基丙烯酰胺微凝胶与线性聚N-异丙基丙烯酰胺-r - N-丙烯酰氧基琥珀酰亚胺基聚合物交联剂形成的。只需调节N-异丙基丙烯酰胺与N的比例聚合物交联剂中的-丙烯酰氧基琥珀酰亚胺，可以控制簇的内部结构；因此，可以调节簇的温度响应。结果表明，当这些微凝胶簇暴露于含有Belousov–Zhabotinsky反应底物的无催化剂溶液中时，它们表现出不同程度的化学机械振荡。