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TCMID 2.0: a comprehensive resource for TCM
Nucleic Acids Research ( IF 14.9 ) Pub Date : 2017-11-02 , DOI: 10.1093/nar/gkx1028
Lin Huang , Duoli Xie , Yiran Yu , Huanlong Liu , Yan Shi , Tieliu Shi , Chengping Wen

As a traditional medical intervention in Asia and a complementary and alternative medicine in western countries, Traditional Chinese Medicine (TCM) is capturing worldwide attention in life science field. Traditional Chinese Medicine Integrated Database (TCMID), which was originally launched in 2013, was a comprehensive database aiming at TCM’s modernization and standardization. It has been highly recognized among pharmacologists and scholars in TCM researches. The latest release, TCMID 2.0 (http://www.megabionet.org/tcmid/), replenished the preceding database with 18 203 herbal ingredients, 15 prescriptions, 82 related targets, 1356 drugs, 842 diseases and numerous new connections between them. Considering that chemical changes might take place in decocting process of prescriptions, which may result in new ingredients, new data containing the prescription ingredients was collected in current version. In addition, 778 herbal mass spectrometry (MS) spectra related to 170 herbs were appended to show the variation of herbal quality in different origin and distinguish genuine medicinal materials from common ones while 3895 MS spectra of 729 ingredients were added as the supplementary materials of component identification. With the significant increase of data, TCMID 2.0 will further facilitate TCM’s modernization and enhance the exploration of underlying biological processes that are response to the diverse pharmacologic actions of TCM.

中文翻译:

TCMID 2.0:TCM的综合资源

作为亚洲的传统医学干预手段以及西方国家的补充和替代医学,传统中药(TCM)在生命科学领域引起了全球关注。中医综合数据库(TCMID)最初于2013年启动,是针对中医现代化和标准化的综合数据库。它已在中药研究中得到了药理学家和学者的高度认可。最新版本TCMID 2.0(http://www.megabionet.org/tcmid/),为之前的数据库补充了18 203种草药成分,15种处方,82种相关目标,1356种药物,842种疾病以及它们之间的许多新联系。考虑到处方的煎熬过程中可能发生化学变化,可能会导致新的成分,因此在当前版本中收集了包含处方成分的新数据。此外,还添加了与170种草药有关的778种草药质谱(MS)光谱,以显示不同来源的草药质量的变化,并区分真正的药材和普通药材,同时添加了729种成分的3895 MS光谱作为成分的补充材料。鉴别。随着数据的大量增加,TCMID 2。
更新日期:2018-01-05
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