The detection of saccharides in biological media is of great current importance for the monitoring of disease states. We have previously reported that solutions of boronic acid-functionalized macrocycles form acyclic oligomeric materials in situ. The oligomers contain fluorescent xanthene moieties. Current efforts are aimed at modulating the spectroscopic responses of these materials for the analysis of specific sugars. We describe conditions whereby the xanthene boronic acids exhibit high colorimetric fructose selectivity. In contrast, at physiological levels selective glucose monitoring can be achieved via fluorescence. Additionally, we describe a method which exhibits promise for detecting both glucose and fructose at dual wavelengths in the UV-Vis region. Mechanistic rationale for each of these findings is presented.

中文翻译：

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大环衍生的功能性黄嘌呤并朝着同时检测葡萄糖和果糖的方向发展。

在生物介质中糖的检测对于监测疾病状态具有重要的当前意义。我们以前曾报道过，硼酸官能化的大环化合物溶液原位形成无环低聚材料。该低聚物包含荧光fluorescent吨部分。当前的努力旨在调节这些材料的光谱响应，以分析特定的糖。我们描述了conditions吨硼酸表现出高比色果糖选择性的条件。相反，在生理水平上可以通过荧光实现选择性的葡萄糖监测。另外，我们描述了一种在紫外-可见光区域的双波长检测葡萄糖和果糖的方法。提出了每个发现的机械原理。