This manuscript discusses the results of studies that were performed to determine optimum capillary electrophoresis (CE) conditions for the enantiomeric resolution of twelve chiral analytes with eight amino acid based polymeric surfactants. The parameters that were optimized include pH, buffer type, and concentration of surfactant. The results indicated that the optimum conditions for enantiomeric separations with the amino acid based polymeric surfactants examined in this study using CE were analyte dependent, not surfactant dependent. In other words, the optimum conditions for a particular analyte were the same for all the amino acid based polymeric surfactants examined in this study. The results of these studies indicate that when using a large group of related amino acid based polymeric surfactants only a few surfactants need to be optimized for each analyte under study. These studies were limited to anionic surfactants that contain the amino acids glycine, L-alanine, L-valine, and L-leucine only. No inference can be necessarily drawn about surfactants containing other types of amino acids such as threonine and serine, which contain extra heteroatoms, or phenylalanine that has an aromatic moiety.

中文翻译：

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用8种聚合表面活性剂优化12种手性分析物。

该手稿讨论了为确定十二种手性分析物与八种氨基酸基聚合物表面活性剂的对映体拆分而确定的最佳毛细管电泳（CE）条件的研究结果。优化的参数包括pH，缓冲液类型和表面活性剂浓度。结果表明，在本研究中使用CE检测的基于氨基酸的聚合物表面活性剂对映体分离的最佳条件取决于分析物，而不取决于表面活性剂。换句话说，对于特定分析物的最佳条件对于本研究中检查的所有基于氨基酸的聚合物表面活性剂都是相同的。这些研究的结果表明，当使用大量相关的基于氨基酸的聚合物表面活性剂时，只需针对每种研究中的分析物优化几种表面活性剂。这些研究仅限于仅包含氨基酸甘氨酸，L-丙氨酸，L-缬氨酸和L-亮氨酸的阴离子表面活性剂。不必推断含有其他类型氨基酸的表面活性剂，例如苏氨酸和丝氨酸，它们含有额外的杂原子，或具有芳族部分的苯丙氨酸。