The cell-based studies of 5, 10, 15, 20-Tetrakis (4-amidinophenyl) porphyrin (Por1), its Zn complex (Por2) and amidinophenyl bisporphyrin (Por3) were carried out to examine their photocytotoxicity, cellular uptake and sub-cellular localization with human nasopharyngeal carcinoma cell (HK-1), using 5, 10, 15, 20-Tetrakis (N-methyl-4-pyridyl) porphyrin (H₂TMPyP) as a reference. These porphyrins showed low dark-cytotoxicity and high photo-cytotoxicity against HK-1. The amphiphilic amidinophenyl bisporphyrin (Por3) displayed better cellular uptake than the single hydrophilic Por1, Por2 and H₂TMPyP. As seen from the extent of overlapping of the fluorescence profiles, lysosomal localization of amidinophenylporphyrin Por1–Por3 and mito/lyso localization of the H₂TMPyP occurred in the cells. The results suggest these porphyrins with amidine group could be used as potential agents in photodynamic therapy.

进行了基于细胞的5、10、15、20-四（4- phy基苯基）卟啉（Por1），其锌配合物（Por2）和a基双联卟啉（Por3）的研究，以检查它们的光细胞毒性，细胞摄取和亚使用5、10、15、20-四（N-甲基-4-吡啶基）卟啉（H ₂ TMPyP）作为参考，对人鼻咽癌细胞（HK-1）进行细胞定位。这些卟啉对HK-1显示出低的暗细胞毒性和高的光细胞毒性。两亲性a基苯基双卟啉（Por3）显示出比单个亲水性Por1，Por2和H ₂更好的细胞摄取TMPyP。从荧光图谱的重叠程度可以看出，细胞中发生了mid基苯基卟啉Por1 - Por3的溶酶体定位和H ₂ TMPyP的线粒体/溶酶定位。结果表明这些带有am基的卟啉可以作为光动力疗法的潜在药物。