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Coded Apertures in Mass Spectrometry
Annual Review of Analytical Chemistry ( IF 5.9 ) Pub Date : 2017-06-12 00:00:00 , DOI: 10.1146/annurev-anchem-061516-045256
Jason J. Amsden 1 , Michael E. Gehm 1 , Zachary E. Russell 2 , Evan X. Chen 1 , Shane T. Di Dona 1 , Scott D. Wolter 3 , Ryan M. Danell 4 , Gottfried Kibelka 5 , Charles B. Parker 1 , Brian R. Stoner 1, 6 , David J. Brady 1 , Jeffrey T. Glass 1
Affiliation  

The use of coded apertures in mass spectrometry can break the trade-off between throughput and resolution that has historically plagued conventional instruments. Despite their very early stage of development, coded apertures have been shown to increase throughput by more than one order of magnitude, with no loss in resolution in a simple 90-degree magnetic sector. This enhanced throughput can increase the signal level with respect to the underlying noise, thereby significantly improving sensitivity to low concentrations of analyte. Simultaneous resolution can be maintained, preventing any decrease in selectivity. Both one- and two-dimensional (2D) codes have been demonstrated. A 2D code can provide increased measurement diversity and therefore improved numerical conditioning of the mass spectrum that is reconstructed from the coded signal. This review discusses the state of development, the applications where coding is expected to provide added value, and the various instrument modifications necessary to implement coded apertures in mass spectrometers.

中文翻译:


质谱中的编码孔径

在质谱分析法中使用编码孔径可能会破坏吞吐量和分辨率之间的折衷,而这种折衷一直困扰着传统仪器。尽管它们的开发还处于初期阶段,但已显示出编码孔径可以将吞吐量提高一个数量级以上,而在简单的90度磁区中分辨率却没有损失。这种提高的通量可以增加有关潜在噪声的信号电平,从而显着提高对低浓度分析物的灵敏度。可以保持同时的分离度,防止选择性降低。一维和二维(2D)代码均已演示。2D代码可以提供增加的测量分集,因此可以改善从编码信号重建的质谱的数值条件。

更新日期:2017-06-12
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