Nowadays, about 150 natural products comprising an allenic or cumulenic structure are known. The chemistry of these compounds has turned out to be a very attractive and prolific area of interest: advances in the isolation and characterization of new allenic natural products have led to the establishment of efficient synthetic procedures which in many cases also open up an access to enantiomerically pure target molecules. Inspired by the intriguing biological activities of many allenic natural products, allene moieties are now systematically introduced in pharmacologically active classes of compounds (steroids, prostaglandins, amino acids, nucleosides). The functionalized allenes thus obtained often exhibit impressive activities as mechanism-based enzyme inhibitors, cytotoxic, or antiviral agents. A prerequisite for further developments in this field is the efficient stereoselective synthesis of allene derivatives.

中文翻译：

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变应原天然产物和药物的合成和性质。

如今，已知约有150种具有艾伦或对苯二酚结构的天然产物。事实证明，这些化合物的化学性质非常吸引人并且是多产的领域：新的烯丙二烯天然产物的分离和表征方面的进展已导致建立了有效的合成方法，在许多情况下，这些方法也为对映体的开发提供了途径。纯目标分子。受到许多艾伦天然产物有趣的生物活性的启发，现在已将艾伦部分系统地引入到具有药理活性的化合物类别（类固醇，前列腺素，氨基酸，核苷）中。如此获得的功能化异位烯通常作为基于机理的酶抑制剂，细胞毒性或抗病毒剂表现出令人印象深刻的活性。